Anti-Npas4 antibody,Abcam,AB76758

Target data Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (PubMed : 18815592, PubMed : 22194569, PubMed : 23029555, PubMed : 24201284, PubMed : 24855953). Plays a key role in the structural and functional plasticity of neurons (PubMed : 23172225). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (PubMed : 24201284, PubMed : 24855953). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (PubMed : 18815592, PubMed : 22194569, PubMed : 24201284). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (PubMed : 24855953). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed : 18815592, PubMed : 22194569, PubMed : 23029555, PubMed : 24201284, PubMed : 27238022). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (PubMed : 25088421). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed : 14701734, PubMed : 15363889, PubMed : 19284974). Can activate the CME (CNS midline enhancer) element (PubMed : 14701734, PubMed : 15363889). See full target information Neuronal PAS domain-containing protein 4