Anti-Nucleolin antibody,Abcam,AB22758

What is this antibody validated in? Anti-Nucleolin antibody (ab22758) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Nucleolin? Anti-Nucleolin (ab22758) specifically detects a band for Nucleolin (UniProt: P19338) at a molecular weight of 76kDa. Trusted by the scientific community Anti-Nucleolin (ab22758) was first used in a scientific publication in 2006 and has been cited over 180 times in peer-reviewed journals. Reviewed by scientists Anti-Nucleolin (ab22758) has over 5 independent reviews from customers.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

IHC-P, ICC/IF, IP, WB, IHC-Fr

Platform ID

BAB718855457

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Nucleolin antibody
Cat. No.AB22758
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationIHC-P, ICC/IF, IP, WB, IHC-Fr
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. See full target information NCL

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