Anti-Nuf2 antibody,Abcam,AB122962

Host

Rabbit

Reactivity

Human

Application

WB, ICC/IF

Platform ID

BAB656873958

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Nuf2 antibody
Cat. No.AB122962
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, ICC/IF
ClonalityPolyclonal
ImmunogenSynthetic Peptide within Human NUF2 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6 - 8.5 Preservative: 0.05% Sodium azide Constituents: 99% Whole serum
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed : 12438418, PubMed : 14654001, PubMed : 15062103, PubMed : 15235793, PubMed : 15239953, PubMed : 15548592, PubMed : 17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed : 15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed : 23085020). See full target information NUF2

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