Anti-OATP1B1 antibody [EPR27070-49],Abcam,AB312838

Target data Mediates the Na(+)-independent uptake of organic anions (PubMed : 10358072, PubMed : 15159445, PubMed : 17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) (PubMed : 10358072, PubMed : 10601278, PubMed : 10873595, PubMed : 11159893, PubMed : 12196548, PubMed : 12568656, PubMed : 15159445, PubMed : 15970799, PubMed : 16627748, PubMed : 17412826, PubMed : 19129463, PubMed : 26979622). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed : 22232210). Involved in the clearance of endogenous and exogenous substrates from the liver (PubMed : 10358072, PubMed : 10601278). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed : 26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs (PubMed : 10601278, PubMed : 15159445, PubMed : 15970799). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate (PubMed : 23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed : 16624871, PubMed : 16627748). Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed : 19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed : 19129463). See full target information SLCO1B1