Anti-OTUD6B antibody,Abcam,AB127714

Host

Rabbit

Reactivity

Human

Application

ICC/IF, WB

Platform ID

BAB034860024

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-OTUD6B antibody
Cat. No.AB127714
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, WB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human OTUD6B aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Isoform 1. Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed : 21267069, PubMed : 27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed : 27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed : 27864334). May also play a role in proteasome assembly and function (PubMed : 28343629).. Isoform 2. Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability. See full target information OTUD6B

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