Anti-OTULIN antibody,Abcam,AB151117

Target data Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed : 23708998, PubMed : 23746843, PubMed : 23806334, PubMed : 23827681, PubMed : 24726323, PubMed : 24726327, PubMed : 26997266, PubMed : 27523608, PubMed : 27559085, PubMed : 28919039, PubMed : 35170849, PubMed : 35587511). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed : 23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed : 23746843, PubMed : 23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex : acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed : 26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed : 27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed : 27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed : 23806334). See full target information OTULIN