Anti-Osteocalcin antibody [EPR24665-63],Abcam,AB309521

Target data The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein : it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed : 8684484). The carboxylated form binds strongly to apatite and calcium (PubMed : 17693256).. The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed : 17693256, PubMed : 20655470, PubMed : 20655471, PubMed : 21333348, PubMed : 24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed : 17693256, PubMed : 20655470, PubMed : 20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes : acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed : 21333348). Also acts as a regulator of brain development : osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed : 24074871, PubMed : 28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed : 24074871). See full target information Bglap