Anti-Osteoprotegerin antibody [bony-1],Abcam,AB18051
Host
Rat
Reactivity
Human
Application
Flow Cyt
Platform ID
BAB347166367
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
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Product Specifications
Scientific Background
Specifications
NameAnti-Osteoprotegerin antibody [bony-1]
Cat. No.AB18051
HostRat
IsotypeIgG2a
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Numberbony-1
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human TNFRSF11B aa 1-250. The exact immunogen used to generate this antibody is proprietary information.
PurityProprietary technique
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. See full target information TNFRSF11B
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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