Anti-PAR-3/PARD3 antibody,Abcam,AB168106

Target data Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed : 10954424, PubMed : 27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed : 27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed : 10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed : 19812038, PubMed : 27925688). See full target information PARD3