Anti-PAR-3/PARD3 antibody,Abcam,AB191204

Host

Rabbit

Reactivity

Mouse, Human

Application

WB

Platform ID

BAB852113991

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PAR-3/PARD3 antibody
Cat. No.AB191204
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationWB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human PARD3 aa 1300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed : 10954424, PubMed : 27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed : 27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed : 10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed : 19812038, PubMed : 27925688). See full target information PARD3

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