Anti-PAX5 antibody [SP34] - ChIP Grade,Abcam,AB227635

What is this antibody validated in? Anti-PAX5 antibody [SP34] - ChIP Grade (ab227635) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), ChIP in Human, Rat samples. What is the molecular weight of PAX5? Anti-PAX5 [SP34] - ChIP Grade (ab227635) specifically detects a band for PAX5 (UniProt: Q02548) at a molecular weight of 42kDa. Collaboration Anti-PAX5 [SP34] - ChIP Grade (ab227635) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Other related products We have a range of other formats of antibody clone [SP34] also available for your convenience: ab227635, Carrier free - ab237773 , ab279606, APC - ab310843 , PE - ab310914 , Alexa Fluor® 488 - ab310945 , Alexa Fluor® 647 - ab311063 , Alexa Fluor® 594 - ab311648 , Alexa Fluor® 568 - ab312921 , Alexa Fluor® 555 - ab313133 , Alexa Fluor® 750 - ab321430

Host

Rabbit

Reactivity

Rat, Human

Application

IP, IHC-P, Flow Cyt (Intra), WB, ChIP

Platform ID

BAB290782180

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PAX5 antibody [SP34] - ChIP Grade
Cat. No.AB227635
HostRabbit
IsotypeIgG
ReactivityRat, Human
ApplicationIP, IHC-P, Flow Cyt (Intra), WB, ChIP
ClonalityMonoclonal
Clone NumberSP34
Concentration0.119 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A/G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed : 10811620, PubMed : 27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed : 10811620, PubMed : 27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed : 32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed : 32612238).. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed : 31941781). Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed : 23678172). See full target information PAX5

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