Anti-PAX8 antibody [SP348] - N-terminal,Abcam,AB227707

Anti-PAX8 antibody [SP348] - N-terminal (ab227707) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ChIC/CUT&RUN-seq, Flow Cyt ICC/IF, IHC-P, WB and mIHC. Abcam's high quality manufacturing and validation processes ensure Anti-PAX8 antibody [SP348] - N-terminal (ab227707) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-PAX8 antibody [SP348] - N-terminal (ab227707) specifically detects PAX8 (UniProt ID: Q06710; Molecular weight: 49kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone SP348 - ab242429 . Antibody clone SP348 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 647 ( ab313345 ). Anti-PAX8 antibody [SP348] - N-terminal (ab227707) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Highly-specific to PAX8. Western blotting data to guarantee specificity to PAX8 with no cross-reactivity with other PAX family members. Validated for CUT&RUN-seq, a key application to map protein-DNA interactions on a genome-wide scale using NGS. A highly-validated antibody for studying PAX8 as a transcription factor, its role in thyroid and renal cancers and epigenetic regulation. This antibody is crucial in cancer research, particularly in understanding PAX8's involvement in tumorigenesis and gene expression and is widely used in studies of embryogenesis and cancers of the Mьllerian duct.

Host

Rabbit

Reactivity

Human

Application

Flow Cyt, IHC-P, ICC/IF, ChIC/CUT&RUN-seq, WB, mIHC

Platform ID

BAB853513319

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-PAX8 antibody [SP348] - N-terminal
Cat. No.AB227707
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationFlow Cyt, IHC-P, ICC/IF, ChIC/CUT&RUN-seq, WB, mIHC
ClonalityMonoclonal
Clone NumberSP348
Concentration0.406 - 0.461 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. See full target information PAX8

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