Anti-PD-L1 antibody [CAL10],Abcam,AB237726
What is this antibody validated in? Anti-PD-L1 antibody [CAL10] (ab237726) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA, Multiplex IHC (mIHC) in Human, samples. What is the molecular weight of PD-L1? Anti-PD-L1 [CAL10] (ab237726) specifically detects a band for PD-L1 (UniProt: Q9NZQ7) at a molecular weight of 33kDa. Trusted by the scientific community Anti-PD-L1 [CAL10] (ab237726) was first used in a scientific publication in 2018 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10μl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-PD-L1 antibody [CAL10] (ab237726) has been confirmed by Western blot testing in CD274 Knockout A549 cell line, ab267054 . Other related products We have a range of other formats of antibody clone [CAL10] also available for your convenience: ab237726, Carrier free - ab251611 , Alexa Fluor® 647 - ab267565 , ab279292 , ab279293 , ab279294 , Carrier free - ab279304 , Carrier free - ab279305 , Carrier free - ab279306 , Alexa Fluor® 555 - ab307643
Host
Rabbit
Reactivity
Human
Application
mIHC, IHC-P, ICC/IF, WB, ELISA, IP
Platform ID
BAB479925141
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Plays a critical role in induction and maintenance of immune tolerance to self (PubMed : 11015443, PubMed : 28813410, PubMed : 28813417, PubMed : 31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed : 11015443, PubMed : 28813410, PubMed : 28813417, PubMed : 36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed : 10581077). Can also act as a transcription coactivator : in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed : 32929201).. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed : 28813410, PubMed : 28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). See full target information CD274
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
Please provide the required information below so that we can quickly source your products.