Anti-PDE8A antibody,Abcam,AB109597

Host

Rabbit

Reactivity

Human

Application

WB, IP

Platform ID

BAB043455896

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PDE8A antibody
Cat. No.AB109597
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IP
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human PDE8A. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed : 18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed : 18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed : 23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed : 23509299). See full target information PDE8A

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