Anti-PDE9A antibody,Abcam,AB168432

Target data Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific : compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed : 18757755, PubMed : 21483814, PubMed : 9624146). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed : 25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). See full target information PDE9A