Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal,Abcam,AB32570
Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ELISA, Flow Cyt (Intra), ICC/IF, IHC-P, IP and WB. Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) was first used in a scientific publication in 1984 and has been cited over 332 times in peer reviewed journals. It's performance in Western blot and IHC in human and mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) has been confirmed by Western Blot testing in PDGFRB knockout SH-SY5Y cells ( ab273749 ). Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) has 31 independent reviews from customers. Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) specifically detects PDGFR alpha (UniProt ID: P09619; Molecular weight: 121kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone Y92 - ab215978 . Antibody clone Y92 is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor ® 488, Alexa Fluor ® 594, Alexa Fluor ® 405, PE, APC ( ab195515 , ab196376 , ab206872 , ab206873 , ab307638 , ab314942 ). Top cited recombinant antibody to PDGRalpha and PDGRbeta on the market with >423 citations. PDGFR alpha and PDGFR beta are key markers in studying cell proliferation, differentiation and angiogenesis, making them invaluable biomarkers for cancer and vascular research Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Shipping conditions update: ambient shipping This product will be delivered at ambient temperature instead of chilled – this is by design. Extensive stability testing confirmed that our products are suitable for shipment under ambient conditions and maintain expected quality. Why the change? It’s part of our commitment to more sustainable packaging solutions, with ambient deliveries using eco-friendly materials such as recyclable cardboard instead of polystyrene. What you need to know Ambient shipments come clearly marked on the delivery note. No ice will be included in ambient shipments, but mixed orders (ambient and cold-chain items) will still arrive with ice packs to protect temperature-sensitive products. Warranty coverage remains fully valid, aligned with our validated shipping method. Please store the product as per the datasheet instructions upon receipt. Find out more - https://www.abcam.com/en-us/support/shipping-storage-support/ambient-shipping
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, ELISA, Flow Cyt (Intra), WB, IP, IHC-P
Platform ID
BAB731249505
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. See full target information PDGFRB Additional targets PDGFRA
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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