Anti-PDIA6 antibody,Abcam,AB11432

Host

Rabbit

Reactivity

Human

Application

WB, ICC/IF

Platform ID

BAB231599337

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-PDIA6 antibody
Cat. No.AB11432
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, ICC/IF
ClonalityPolyclonal
ImmunogenSynthetic Peptide within Human PDIA6 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.01% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed : 12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed : 24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed : 24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed : 15466936). See full target information PDIA6

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