Anti-PDK1 antibody [2H3AA11],Abcam,AB110335

This monoclonal antibody to PDK1 has been knockout validated in Western blot. The expected band for PDK1 was observed in wild type cells and the band was not seen in knockout cells. Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Human

Application

WB, ICC/IF, Flow Cyt

Platform ID

BAB106636819

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PDK1 antibody [2H3AA11]
Cat. No.AB110335
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationWB, ICC/IF, Flow Cyt
ClonalityMonoclonal
Clone Number2H3AA11
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityProprietary technique
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.5 Preservative: 0.02% Sodium azide Constituents: HEPES buffered saline
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. See full target information PDK1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.