Anti-PDK1 antibody [4A11],Abcam,AB110025

Host

Mouse

Reactivity

Mouse, Rat, Human, African green monkey, Monkey

Application

Flow Cyt, IHC-P, WB, ELISA, ICC/IF

Platform ID

BAB419143066

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PDK1 antibody [4A11]
Cat. No.AB110025
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Human, African green monkey, Monkey
ApplicationFlow Cyt, IHC-P, WB, ELISA, ICC/IF
ClonalityMonoclonal
Clone Number4A11
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human PDK1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. See full target information PDK1

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