Anti-PDX1 antibody,Abcam,AB47267
What is this antibody validated in? Anti-PDX1 antibody (ab47267) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. Trusted by the scientific community Anti-PDX1 (ab47267) was first used in a scientific publication in 2007 and has been cited over 100 times in peer-reviewed journals. Reviewed by scientists Anti-PDX1 (ab47267) has over 15 independent reviews from customers.
Host
Rabbit
Reactivity
Human
Application
ICC/IF, IHC-P
Platform ID
BAB169517886
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1 : PBX1b : MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. See full target information PDX1
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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