Anti-PDX1 antibody,Abcam,AB47308

What is this antibody validated in? Anti-PDX1 antibody (ab47308) is a guinea pig polyclonal antibody and is validated for use in Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse, Rat samples. Trusted by the scientific community Anti-PDX1 (ab47308) was first used in a scientific publication in 2007 and has been cited over 40 times in peer-reviewed journals.

Host

Guinea pig

Reactivity

Mouse, Rat

Application

ICC/IF

Platform ID

BAB482024133

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-PDX1 antibody
Cat. No.AB47308
HostGuinea pig
IsotypeIgG
ReactivityMouse, Rat
ApplicationICC/IF
ClonalityPolyclonal
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1 : PBX1b : MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'. See full target information Pdx1

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