Anti-PEX14 antibody,Abcam,AB109999

Target data Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed : 24235149, PubMed : 28765278, PubMed : 9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed : 24235149, PubMed : 28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed : 21525035). See full target information PEX14