Anti-PEX5/PER3 antibody,Abcam,AB204444

Target data Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed : 11101887, PubMed : 11336669, PubMed : 12456682, PubMed : 16314507, PubMed : 17157249, PubMed : 17428317, PubMed : 21976670, PubMed : 26344566, PubMed : 7706321, PubMed : 7719337, PubMed : 7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed : 12456682, PubMed : 17157249, PubMed : 21976670, PubMed : 26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed : 11336669, PubMed : 24662292).. Isoform 1. In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed : 11336669, PubMed : 11546814, PubMed : 25538232, PubMed : 33389129, PubMed : 9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed : 25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed : 25538232).. Isoform 2. Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. See full target information PEX5