Anti-PGC1 alpha antibody,Abcam,AB191838
This product may be covered by one or more of the following U.S. Patents. 6,166,192 6,426,411 6,525,178 6,872,391 6,908,987 7,250,283 7,091,006 7,354,738 8,105,774 8,445,233 Product Specifications Anti-PGC1 alpha antibody (ab191838) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse, rat samples. Anti-PGC1 alpha antibody (ab191838) specifically detects PGC1 alpha (UniProt ID: Q9UBK2; Molecular weight: 91kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-PGC1 alpha antibody (ab191838) has high sensitivity and specificity. Anti-PGC1 alpha antibody (ab191838) has been cited over 68 times in peer reviewed journals and is trusted by the scientific community.
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, IHC-P, WB
Platform ID
BAB933885986
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Acts as a key regulator of gluconeogenesis : stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed : 16753578, PubMed : 23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed : 23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). See full target information PPARGC1A
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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