Anti-PGC1 alpha + beta antibody - BSA and Azide free,Abcam,AB54481
What is this antibody validated in? Anti-PGC1 alpha + beta antibody - BSA and Azide free (ab54481) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB) in Human, Mouse samples. What is the molecular weight of PGC1 alpha + beta? Anti-PGC1 alpha + beta - BSA and Azide free (ab54481) specifically detects a band for PGC1 alpha + beta (UniProt: Q9UBK2) at a molecular weight of 92kDa. Trusted by the scientific community Anti-PGC1 alpha + beta - BSA and Azide free (ab54481) was first used in a scientific publication in 2007 and has been cited over 540 times in peer-reviewed journals. Reviewed by scientists Anti-PGC1 alpha + beta - BSA and Azide free (ab54481) has over 20 independent reviews from customers. This product may be covered by one or more of the following U.S. Patents. 6,166,192 6,426,411 6,525,178 6,872,391 6,908,987 7,250,283 7,091,006 7,354,738 8,105,774 8,445,233
Host
Rabbit
Reactivity
Mouse, Human
Application
WB
Platform ID
BAB496417221
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed : 10713165, PubMed : 20005308, PubMed : 21376232). Acts as a key regulator of gluconeogenesis : stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed : 16753578, PubMed : 23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed : 23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). See full target information PPARGC1A Additional targets PPARGC1B
Category Paths
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