Anti-PHF17 antibody,Abcam,AB66968

Host

Mouse

Reactivity

Human

Application

WB, ICC/IF

Platform ID

BAB309573156

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PHF17 antibody
Cat. No.AB66968
HostMouse
IsotypeIgG
ReactivityHuman
ApplicationWB, ICC/IF
ClonalityPolyclonal
Concentration0.81 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human JADE1.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed : 16387653, PubMed : 19187766, PubMed : 20129055, PubMed : 24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed : 20129055, PubMed : 24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed : 15502158). Promotes apoptosis (PubMed : 16046545). May act as a renal tumor suppressor (PubMed : 16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed : 22654112). See full target information JADE1

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