Anti-PI 3 Kinase p85 alpha antibody [EPR18702],Abcam,AB191606
What is this antibody validated in? Anti-PI 3 Kinase p85 alpha antibody [EPR18702] (ab191606) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF) in African green monkey, Human, Mouse, Rat samples. What is the molecular weight of PI 3 Kinase p85 alpha? Anti-PI 3 Kinase p85 alpha [EPR18702] (ab191606) specifically detects a band for PI 3 Kinase p85 alpha (UniProt: Q63787) at a molecular weight of 84kDa. Trusted by the scientific community Anti-PI 3 Kinase p85 alpha [EPR18702] (ab191606) was first used in a scientific publication in 2016 and has been cited over 220 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-PI 3 Kinase p85 alpha antibody [EPR18702] (ab191606) has been confirmed by Western blot testing in PIK3R1 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR18702] also available for your convenience: ab191606, Carrier free - ab223792 , APC - ab225369 , PE - ab225370 , Alexa Fluor® 488 - ab225371 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human, African green monkey
Application
ICC/IF, WB, Flow Cyt (Intra), IP
Platform ID
BAB185710110
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed : 17626883, PubMed : 19805105, PubMed : 7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed : 20348923). See full target information PIK3R1
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