Anti-PITRM1 antibody,Abcam,AB111681

Target data Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed : 10360838, PubMed : 16849325, PubMed : 19196155, PubMed : 24931469). Has an ATP-independent activity (PubMed : 16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed : 19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed : 10360838, PubMed : 19196155, PubMed : 24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed : 19196155). Also degrades other unstructured peptides (PubMed : 19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed : 16849325, PubMed : 24931469, PubMed : 26697887). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed : 24931469, PubMed : 29383861, PubMed : 29764912). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed : 24931469). It is also able to degrade amyloid-beta protein 42 (PubMed : 29764912). See full target information PITRM1