Anti-PKMYT1 antibody,Abcam,AB221738

Host

Rabbit

Reactivity

Human

Application

ICC/IF

Platform ID

BAB562996512

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PKMYT1 antibody
Cat. No.AB221738
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF
ClonalityPolyclonal
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human PKMYT1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed : 10373560, PubMed : 10504341, PubMed : 9001210, PubMed : 9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed : 9001210, PubMed : 9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed : 9001210, PubMed : 9268380). See full target information PKMYT1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.