Anti-PLEKHM2 antibody,Abcam,AB91581

Target data Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed : 22172677, PubMed : 24088571, PubMed : 25898167, PubMed : 28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed : 24088571). Required for maintenance of the Golgi apparatus organization (PubMed : 22172677). May play a role in membrane tubulation (PubMed : 15905402). See full target information PLEKHM2