Anti-PMS2 antibody [EPR3947],Abcam,AB110638
To see more of the key markers and tools you need to study the hallmarks of cancer, including genome instability and mutation, please visit the following page . Product Specifications Anti-PMS2 antibody [EPR3947] (ab110638) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human samples. Anti-PMS2 antibody [EPR3947] (ab110638) specifically detects PMS2 (UniProt ID: P54278; Molecular weight: 96kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-PMS2 antibody [EPR3947] (ab110638) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PMS2 antibody [EPR3947] (ab110638) has been confirmed by testing in knockout samples. Anti-PMS2 antibody [EPR3947] (ab110638) has been cited over 36 times in peer reviewed journals and is trusted by the scientific community. Related Products Antibody clone EPR3947 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 555, PE, APC, HRP, Alkaline Phosphatase, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 750 ( ab202835 , ab203457 , ab303014 , ab303015 , ab303016 , ab308700 , ab310420 , ab312418 , ab320964 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
ICC/IF, IHC-P, Flow Cyt (Intra), IP, WB
Platform ID
BAB689858118
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Component of the post-replicative DNA mismatch repair system (MMR) (PubMed : 30653781, PubMed : 35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed : 35189042). See full target information PMS2
Category Paths
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