Anti-PODXL antibody [EPR9518],Abcam,AB150358
What is this antibody validated in? Anti-PODXL antibody [EPR9518] (ab150358) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of PODXL? Anti-PODXL [EPR9518] (ab150358) specifically detects a band for PODXL (UniProt: O00592) at a molecular weight of 58kDa. Trusted by the scientific community Anti-PODXL [EPR9518] (ab150358) was first used in a scientific publication in 2012 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-PODXL antibody [EPR9518] (ab150358) has been confirmed by Western blot testing in PODXL Knockout HAP1 cell line, ab266887 . Other related products We have a range of other formats of antibody clone [EPR9518] also available for your convenience: ab150358, Alexa Fluor® 488 - ab208254 , Alexa Fluor® 568 - ab211225 , Carrier free - ab269888 , Alexa Fluor® 647 - ab307402 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
WB, Flow Cyt (Intra), ICC/IF, IHC-P
Platform ID
BAB940282914
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. See full target information PODXL
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