Anti-PPM1D/WIP1 antibody [OTI3E1],Abcam,AB236515

Host

Mouse

Reactivity

Human

Application

WB

Platform ID

BAB879400887

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PPM1D/WIP1 antibody [OTI3E1]
Cat. No.AB236515
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationWB
ClonalityMonoclonal
Clone NumberOTI3E1
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human PPM1D aa 1-400. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Involved in the negative regulation of p53 expression (PubMed : 23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed : 15870257, PubMed : 16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed : 21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). See full target information PPM1D

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