Anti-PR3 antibody [WGM2],Abcam,AB91181

ab91181 blocks the PR3 activity and partially inhibits the binding of Human PR3-ANCA to PR3; it can be used in immuno assays, for inhibition of biological PR3 activity and induction of monocytes and neutrophils activation.

Host

Mouse

Reactivity

Human

Application

FuncS (Neut/Block), WB, IHC-Fr, ELISA, Flow Cyt, IHC-P

Platform ID

BAB255088057

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PR3 antibody [WGM2]
Cat. No.AB91181
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationFuncS (Neut/Block), WB, IHC-Fr, ELISA, Flow Cyt, IHC-P
ClonalityMonoclonal
Clone NumberWGM2
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationConstituents: PBS, 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed : 2033050, PubMed : 28240246, PubMed : 3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed : 23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed : 22266279). See full target information PRTN3

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