Anti-PSD95 antibody [7E3-1B8] - Synaptic Marker,Abcam,AB13552

What is this antibody validated in? Anti-PSD95 antibody [7E3-1B8] - Synaptic Marker (ab13552) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Cow, Human, Mouse, Rat samples. Trusted by the scientific community Anti-PSD95 [7E3-1B8] - Synaptic Marker (ab13552) was first used in a scientific publication in 2004 and has been cited over 50 times in peer-reviewed journals.

Host

Mouse

Reactivity

Mouse, Rat, Cow, Human

Application

ICC/IF, IHC-P, Flow Cyt, WB

Platform ID

BAB634073643

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PSD95 antibody [7E3-1B8] - Synaptic Marker
Cat. No.AB13552
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Cow, Human
ApplicationICC/IF, IHC-P, Flow Cyt, WB
ClonalityMonoclonal
Clone Number7E3-1B8
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Rat Dlg4.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed : 26334723). See full target information DLG4

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