Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker,Abcam,AB238135
Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (ab238135) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-Fr, IHC-P, IP, WB in human, mouse, rat samples. Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (ab238135) has been cited over 24 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (ab238135) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (ab238135) has been confirmed by testing in knockout samples. Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (ab238135) has 4 independent reviews from customers. Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (ab238135) specifically detects PSD95 (UniProt ID: Q62108; Molecular weight: 80kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR23124-118 - ab269863 . Antibody clone EPR23124-118 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 568 ( ab32566 , ab32571 , ab3286 ). Post Synaptic Density 95 kDa (PSD-95), also known as synapse-associated protein 90 kDa (SAP90), is a vital protein located in the postsynaptic density of neurons. It plays a key role in synaptic signaling and plasticity by organizing and anchoring various synaptic proteins, such as NMDA receptors and potassium channels. Changes in PSD-95 expression are associated with several neurological and psychiatric disorders, including schizophrenia, autism, and Alzheimer's disease (AD). Research on PSD-95 is crucial for understanding synaptic function and dysfunction, emphasizing its importance in the study of neurodegenerative and neuropsychiatric diseases. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, IHC-Fr, WB, IP
Platform ID
BAB571592384
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed : 15358775, PubMed : 9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity). See full target information Dlg4
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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