Anti-PSD95 antibody - Synaptic Marker,Abcam,AB18258

Anti-PSD95 antibody - Synaptic Marker (ab18258) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P and WB. Anti-PSD95 antibody - Synaptic Marker (ab18258) was first used in a scientific publication in 2001 and has been cited over 366 times in peer reviewed journals. It's performance in Western blot and IHC in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-PSD95 antibody - Synaptic Marker (ab18258) has high sensitivity and specificity. The specificity of Anti-PSD95 antibody - Synaptic Marker (ab18258) has been confirmed by WB testing in PSD95 knockout SH-SY5Y cells ( ab280043 ). Anti-PSD95 antibody - Synaptic Marker (ab18258) has 39 independent reviews from customers. Anti-PSD95 antibody - Synaptic Marker (ab18258) specifically detects PSD95 (UniProt ID: P78352; Molecular weight: 81kDa) and is sold in 100 ug selling sizes. PSD95 (Postsynaptic Density Protein 95), encoded by gene DLG4, is a crucial scaffolding protein in neuro research, particularly for its role in synaptic stability and plasticity. It is involved in the organization of synaptic signaling complexes and the regulation of synaptic strength. Researchers use PSD95 to study synaptic development, neurotransmitter receptor localization and the effects of neurological disorders such as stroke and traumatic brain injury (TBI). Its expression helps in understanding synaptic function and the molecular mechanisms underlying synaptic plasticity and neuroprotection.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

WB, IHC-P, ICC/IF

Platform ID

BAB134123619

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-PSD95 antibody - Synaptic Marker
Cat. No.AB18258
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationWB, IHC-P, ICC/IF
ClonalityPolyclonal
Concentration0.9 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed : 26334723). See full target information DLG4

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