Anti-PSPC1 antibody [1L4] - C-terminal,Abcam,AB214012

Host

Mouse

Reactivity

Mouse, Human

Application

ICC/IF, WB

Platform ID

BAB259985705

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-PSPC1 antibody [1L4] - C-terminal
Cat. No.AB214012
HostMouse
IsotypeIgG1
ReactivityMouse, Human
ApplicationICC/IF, WB
ClonalityMonoclonal
Clone Number1L4
Concentration1.5 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Mouse Pspc1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data RNA-binding protein required for the formation of nuclear paraspeckles (PubMed : 22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed : 22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed : 28712728). See full target information PSPC1

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