Anti-PTBP1 antibody [EPR9048(B)],Abcam,AB133734
What is this antibody validated in? Anti-PTBP1 antibody [EPR9048(B)] (ab133734) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of PTBP1? Anti-PTBP1 [EPR9048(B)] (ab133734) specifically detects a band for PTBP1 (UniProt: P26599) at a molecular weight of 57kDa. Trusted by the scientific community Anti-PTBP1 [EPR9048(B)] (ab133734) was first used in a scientific publication in 2012 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-PTBP1 antibody [EPR9048(B)] (ab133734) has been confirmed by Western blot testing in PTBP1 Knockout HAP1 cell line, ab265155 . Other related products We have a range of other formats of antibody clone [EPR9048(B)] also available for your convenience: ab133734, Alexa Fluor® 647 - ab201020 , Carrier free - ab240079 , PE - ab305838 , APC - ab305839 , HRP - ab305840 , Alkaline Phosphatase - ab308831 , Alexa Fluor® 488 - ab309768 , Alexa Fluor® 594 - ab310562 , Alexa Fluor® 555 - ab312091 , Alexa Fluor® 568 - ab312571 , Alexa Fluor® 750 - ab321066 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Human
Application
IHC-P, Flow Cyt (Intra), ICC/IF, WB
Platform ID
BAB760135633
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed : 15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed : 14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed : 20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed : 21518806). See full target information PTBP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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