Anti-PTP1B antibody [OTI1D10],Abcam,AB124375

The clone number has been updated from 1D10 to OTI1D10, both clone numbers name the same clone.

Host

Mouse

Reactivity

Rat, Dog, Human, African green monkey

Application

WB, ICC/IF, IHC-P, Flow Cyt (Intra)

Platform ID

BAB760735345

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-PTP1B antibody [OTI1D10]
Cat. No.AB124375
HostMouse
IsotypeIgG2a
ReactivityRat, Dog, Human, African green monkey
ApplicationWB, ICC/IF, IHC-P, Flow Cyt (Intra)
ClonalityMonoclonal
Clone NumberOTI1D10
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human PTPN1.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. See full target information PTPN1

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