Anti-Pannexin 1 antibody,Abcam,AB139715

Target data Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed : 15304325, PubMed : 16908669, PubMed : 20829356, PubMed : 20944749, PubMed : 30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities : nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed : 32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed : 16908669).. Caspase-activated pannexin-1. During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells. See full target information PANX1