Anti-Polymeric immunoglobulin receptor/PIGR antibody,Abcam,AB96196
What is this antibody validated in? Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of Polymeric immunoglobulin receptor/PIGR? Anti-Polymeric immunoglobulin receptor/PIGR (ab96196) specifically detects a band for Polymeric immunoglobulin receptor/PIGR (UniProt: P01833) at a molecular weight of 83kDa. Reviewed by scientists Anti-Polymeric immunoglobulin receptor/PIGR (ab96196) has over 5 independent reviews from customers.
Host
Rabbit
Reactivity
Human
Application
WB, ICC/IF, IHC-P
Platform ID
BAB753438849
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Polymeric immunoglobulin receptor. Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.. Secretory component. Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed : 12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed : 16543244). See full target information PIGR
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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