Anti-RAMP3 antibody,Abcam,AB197372

Host

Rabbit

Reactivity

Human

Application

IHC-P

Platform ID

BAB639471051

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-RAMP3 antibody
Cat. No.AB197372
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P
ClonalityPolyclonal
Concentration1.2 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human Receptor activity-modifying protein 3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed : 23674134, PubMed : 9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed : 23674134, PubMed : 9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed : 23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed : 32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed : 35324283). See full target information Receptor activity-modifying protein 3

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