Anti-RCC2 antibody,Abcam,AB70788

Target data Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed : 12919680, PubMed : 25074804, PubMed : 26158537, PubMed : 28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed : 12919680, PubMed : 23388455, PubMed : 26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed : 12919680, PubMed : 26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed : 23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed : 26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed : 25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed : 25074804, PubMed : 28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed : 25074804, PubMed : 28869598). See full target information RCC2