Anti-ROCK2 + ROCK1 antibody [EP786Y],Abcam,AB45171
What is this antibody validated in? Anti-ROCK2 + ROCK1 antibody [EP786Y] (ab45171) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Cow, Human, Mouse, Rat samples. What is the molecular weight of ROCK1? Anti-ROCK2 + ROCK1 [EP786Y] (ab45171) specifically detects a band for ROCK1 (UniProt: Q13464) at a molecular weight of 158kDa. Trusted by the scientific community Anti-ROCK2 + ROCK1 [EP786Y] (ab45171) was first used in a scientific publication in 2006 and has been cited over 130 times in peer-reviewed journals. Reviewed by scientists Anti-ROCK2 + ROCK1 [EP786Y] (ab45171) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EP786Y] also available for your convenience: ab45171, Alexa Fluor® 488 - ab205432 , Carrier free - ab219587 , PE - ab224972 , APC - ab310864 , Alexa Fluor® 647 - ab311078 , Alexa Fluor® 594 - ab311669 , Alexa Fluor® 568 - ab312944 , Alexa Fluor® 555 - ab313154 , Alexa Fluor® 750 - ab321633 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human, Cow
Application
IHC-P, WB, IP, Flow Cyt (Intra), ICC/IF, IHC-Fr
Platform ID
BAB771630113
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed : 10436159, PubMed : 10652353, PubMed : 11018042, PubMed : 11283607, PubMed : 17158456, PubMed : 18573880, PubMed : 19131646, PubMed : 8617235, PubMed : 9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed : 10436159, PubMed : 10652353, PubMed : 11018042, PubMed : 11283607, PubMed : 17158456, PubMed : 18573880, PubMed : 19131646, PubMed : 23093407, PubMed : 23355470, PubMed : 8617235, PubMed : 9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed : 18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed : 19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed : 19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed : 21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed : 19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). See full target information ROCK1 Additional targets ROCK2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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