Anti-RUNX1T1/ETO/CDR antibody - ChIP Grade,Abcam,AB195329

Target data Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed : 10688654, PubMed : 12559562, PubMed : 15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed : 23251453). Can repress transactivation mediated by TCF12 (PubMed : 16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed : 23812588). See full target information RUNX1T1