Anti-RUNX2 antibody [2B9],Abcam,AB76956

This product was changed from ascites to tissue culture supernatant on 15 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team. Product Specifications Anti-RUNX2 antibody [2B9] (ab76956) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, WB in human, rat, samples. Anti-RUNX2 antibody [2B9] (ab76956) specifically detects RUNX2 (UniProt ID: Q13950; Molecular weight: 57kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-RUNX2 antibody [2B9] (ab76956) has high sensitivity and specificity. Anti-RUNX2 antibody [2B9] (ab76956) has been cited over 324 times in peer reviewed journals and is trusted by the scientific community. Anti-RUNX2 antibody [2B9] (ab76956) has 7 independent reviews from customers.

Host

Mouse

Reactivity

Rat, Human

Application

WB, Flow Cyt, ICC/IF

Platform ID

BAB399441263

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-RUNX2 antibody [2B9]
Cat. No.AB76956
HostMouse
IsotypeIgG2a
ReactivityRat, Human
ApplicationWB, Flow Cyt, ICC/IF
ClonalityMonoclonal
Clone Number2B9
Concentration0.49 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human RUNX2 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed : 28505335, PubMed : 28703881, PubMed : 28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation : synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. See full target information RUNX2

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.