Anti-Rab1A antibody [EPR27169-83],Abcam,AB302545
Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected] Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human, Mouse, Rat
Application
IP, Flow Cyt (Intra), ICC/IF, Dot, IHC-P, WB
Platform ID
BAB762434529
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed : 20639577, PubMed : 20861236, PubMed : 21303926, PubMed : 22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed : 20639577, PubMed : 20861236, PubMed : 21303926, PubMed : 22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed : 21303926). Required to modulate the compacted morphology of the Golgi (PubMed : 26209634). Regulates the level of CASR present at the cell membrane (PubMed : 20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed : 20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed : 22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). See full target information RAB1A
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