Anti-Rab5 antibody [EPR21801] - Early Endosome Marker,Abcam,AB218624
What is this antibody validated in? Anti-Rab5 antibody [EPR21801] - Early Endosome Marker (ab218624) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Rab5? Anti-Rab5 [EPR21801] - Early Endosome Marker (ab218624) specifically detects a band for Rab5 (UniProt: P20339) at a molecular weight of 24kDa. Trusted by the scientific community Anti-Rab5 [EPR21801] - Early Endosome Marker (ab218624) was first used in a scientific publication in 2018 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Rab5 antibody [EPR21801] - Early Endosome Marker (ab218624) has been confirmed by Immunocytochemistry/ Immunofluorescence testing in RAB5A Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR21801] also available for your convenience: ab218624, Carrier free - ab231095 , Alexa Fluor® 488 - ab270094 , PE - ab302987 , APC - ab302988 , HRP - ab302989 , Alkaline Phosphatase - ab308673 , Alexa Fluor® 647 - ab310008 , Alexa Fluor® 594 - ab310375 , Alexa Fluor® 555 - ab311900 , Alexa Fluor® 568 - ab312371 , Alexa Fluor® 750 - ab321399 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Rat, Human, Mouse
Application
IP, ICC/IF, Flow Cyt (Intra), IHC-P, WB
Platform ID
BAB513009253
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed : 10818110, PubMed : 14617813, PubMed : 15378032, PubMed : 16410077). Contributes to the regulation of filopodia extension (PubMed : 14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed : 22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). See full target information RAB5A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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