Anti-Rabphilin 3A antibody,Abcam,AB3338

Host

Rabbit

Reactivity

Mouse, Rat

Application

WB, ICC/IF

Platform ID

BAB325965284

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Rabphilin 3A antibody
Cat. No.AB3338
HostRabbit
IsotypeIgG
ReactivityMouse, Rat
ApplicationWB, ICC/IF
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Rat Rph3a aa 1-50. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationConstituents: PBS, 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed : 16203731, PubMed : 8617225). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed : 8617225). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed : 26679993). Also plays a role in the exocytosis of arginine vasopressin hormone (PubMed : 29367474). See full target information Rph3a

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